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The cytokine status and the levels of thyroid hormones in children with acute respiratory viral infections

Year: 2018, volume 14 Issue: №1 Pages: 61-65
Heading: Infectious Diseases Article type: Original article
Authors: Malinina N.V., Malyugina T.N.
Organization: Saratov State Medical University
Summary:

The research goal is to study the performance of INF-а, INF-y and IL-1(3 in children with acute respiratory viral infection (ARVI) depending on etiology, the presence of mixed infection, disease severity, presence of complications, the concentration of thyroid hormones. Material and Methods. Examined 147 patients aged from 1 to 10 years at the outbreak of the ARVI and 15 healthy children. Patients in the midst of acute respiratory infections was conducted to determine levels of IL-1(3, INF-а, INF-y, triiodothyronine (T3) and free thyroxine free (T4) by ELISA using standard test kits JSC "Vector-best" (Koltsovo, Novosibirsk region). Results. It was showed elevated level of INF-y in patients with PC-infection in comparison with the same indicator in healthy children. Set the increased level of INF-а in severe ARVI and the level of INF-y at medium severe form. It was showed increased levels of INF-y in patients with mixed infection. In children with complications, the level of IL-1 (3 was lower almost in 2.4 times, than in children without complications. Among patients with complications, the highest numbers of INF-а were detected in children with pneumonia and INF-y increased in patients with bronchitis. When conducting correlation analysis, the highest rates of INF-а were observed in children with the syndrome of "low T3", and INF-y in children as low T3 and low T4. Conclusion. An increase in the level of INF-y in patients with RS infection was found. Revealed that in children in acute period of SARS levels IL-1 IS, INF-а do not depend on the etiological factor of SARS. These indicators are influenced by the severity of the disease, which in our study was due to the development of mixed infection, the presence and nature of complications. High rates of INF-а and INF-y have significant inverse correlation with the level of T3, which reflects the degree of intoxication in the acute period of infectious diseases.

Keywords: adenovirus infection, children, cytokines, interferon-y, interferon-а, interleukin-1 p, parainfluenza, respiratory syncytial infection

Bibliography:
1. Gavrisheva NA, Antonova TV. Infectious process: clinical and pathophysiological aspects: a tutorial. SPb.: ELBI-SPb, 2006; 288 p.
2. Kotovan IM, Shipilov MV. Level of interleukin-1 p in patients with acute respiratory viral infections. Scientific notes of Orel State University. Series: natural, technical and medical sciences 2011; (3): 257-60
3. Samotrueva MA, Tepliy DL, Tyurenkov JN. Ways of realization of neuro-immuno-endocrine interactions. Natural sciences 2009; (4): 112-30
4. Sheplagina LA. Age characteristics of immunity in children. Russian medical journal 2009; (23): 1564-8
5. Zaitsev АА. The direction of pharmacotherapy and prevention of acute respiratory viral infections. Russian medical journal 2009; (23): 1525-8
6. Zakharova IN, Malinovskaya VV, Korovina NA, et al. Clinical and immunological rationale for topical application of interferons upon respiratory virus infection in children. Issues of Modern Pediatrics. 2011; (5): 117-22
7. Golovacheva EG, Osidak LV, Obraztsova EV, Afanasieva Ol. Production of interferon in children with acute respiratory viral infections. Medical Immunology 2009; (2-3): 205-14
8. Melendi GA., Laham FR, et al. Cytokine Profiles in the Respiratory Tract during Primary Infection With Human Metapneumovirus, Respiratory Syncytial Virus, or Influenza Virus in Infants. Pediatrics 2007; 120 (2): 410-5
9. Semple MG, Dankert HM, et al. Severe respiratory syncytial virus bronchiolitis in infants is associated with reduced airway interferon gamma and substance P. PLoS One 2007; 2 (10): 1-7
10. Jaglova NV Morphological and biochemical studies of secretory activity of thyroid gland in experimental nonthyroidal illness syndrome: DSc abstract. M., 2011; 44 p.
11. Hod'ko ОК. Adaptive-compensatory reactions in primary and secondary immune deficiency in children: PhD abstract. Ekaterinburg, 2006; 24 p.
12. Malugina TN, Malinina NV, Mihailova EV. Status of the pituitary-thyroid system in children with acute respiratory viral infections. Infection diseases. 2015; (2): 39-45
13. Aberle JH, Rebhandl W, et al. Decreased interferon-gamma response in respiratory syncytial virus compared to other respiratory viral infections in infants. Clin Exp Immunol 2004; 137 (1): 146-50
14. Ershov Fl, Kiselev Ol. Interferons and their inducers (from molecules to medicines). M.: GEOTAR-Media, 2005; 368 p.

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