Saratov JOURNAL of Medical and Scientific Research

Dynamics of acetylcholine receptors antibody titer in myasthenia gravis

Year: 2018, volume 14 Issue: №1 Pages: 164-168
Heading: Neurology Article type: Original article
Authors: Romanova T.V., Poverennova I.E., Zakharov A.V.
Organization: Samara State Medical University
Summary:

The aim was to examine the longitudinal association between myasthenia gravis clinical severity and concentration of acetylcholine receptor (AChR) antibodies to evaluate if AChR-antibody variations correlate to disease severity. Material and Methods. Antibodies were determined by enzyme immunoassay. The International Clinical Classification (MGFA) was used to grade the severity of the disease. The level of antibodies was compared with the severity of the condition and the form of the disease at the stage of diagnosis in 65 patients, as well as in repeated studies in 26 patients. Results. The titer of AChR-antibodies did not correlate with the severity of the condition, however, a direct relationship between the change in the level of acetylcholine receptor antibodies and the change in the clinical state during the course of the disease was obtained. Conclusion. Repeated AChR-antibody measurements will help to predict the clinical state of the patient and can be used to correct immunosuppressive therapy.

Bibliography:
1 Lindstrom J. Acetylcholine receptor and myasthenia. Muscle & Nerve 2000; 23: 453-477
2 Romi F, et al. Muscle autoantibodies in subgroups of myasthenia gravis. Neurol 2000; 247: 369-375
3 Heldal AT, et al. Repeated Acetylcholine Receptor Antibody-Concentrations and Association to Clinical Myasthenia Gravis Development. Published online 2014 Dec. 2 DOI: 10.1371/journal.pone. 114060
4 Oosterhuis HJ, Limburg PS, Hummel-Tappel E. Anti-acetylcholine receptor antibodies in myasthenia gravis. Part 2: Clinical and serological follou-up of individual patients. Neurol Sci 1983;58:371-385
5 Sidnev DV, etal. Antibodies to the acetylcholine receptor in patients with various clinical forms of myasthenia and myasthenic syndrome Lambert-Eaton. S. S. Korsakov Journal of Neurology and Psychiatry 2006; 106 (1): 53-55
6 Gekht ВМ, et al. The role of antibodies to the acetylcholine receptor in the pathogenesis of myasthenia gravis. Neurological Journal 2002; 6: 18-21
7 Leite Ml, Waters Р, VincentA. Diagnostic use of autoantibodies in myasthenia gravis. Autoimmunity 2010; 43: 371-379
8 Romanova TV. Study of antibodies to acetylcholine receptors in patients with myasthenia gravis. Bulletin of the East Siberian Scientific Center of the Siberian Branch of the Russian Academy of Medical Sciences 2013; 2 (1): 82-86
9 Vincent A, Newsom-Davis J, Newton Р, Beck N. Acetylcholine receptor autoantibody and clinical resporse to thymectomy in myasthenia gravis. Neurology 1983; 33(10): 1276-1282
10 Drachman DB, Adams RN, Josifek LF, Self SG. Functional activities of autoantibodies to acetylcholine receptors and the clinical severety of myasthenia gravis. N Engl J Med 1982;307:769-773
11 Sidnev DV, et al. Antibodies to the acetylcholine receptor in the evaluation of the effectiveness of pathogenetic therapy in patients with myasthenia gravis. S. S. Korsakov Journal of Neurology and Psychiatry 2010; 110 (11): 37-40
12 Sanders DB, et al. Does change in AChR antibody level correlate with clinical change in MG? Muscle Nerve 2014; 49 (4): 483-486
13 Jaretzki A, et al. Myasthenia gravis: recommendations for clinical research standards / Task Force of the Medical Scientific Advisory Board of the Myasthenia Gravis Foundation of America. Ann Thorac Surg 2000; 70: 327-334.

AttachmentSize
2018_01-1_164-168.pdf312.76 KB

No votes yet