Saratov JOURNAL of Medical and Scientific Research

Clinical and immunological features of multiple sclerosis combined with persistent herpes viral infection

Year: 2018, volume 14 Issue: №1 Pages: 126-132
Heading: Neurology Article type: Original article
Authors: Goncharova Z.A., Belovolova R.A., Megerian V.A.
Organization: City Hospital №1 n.a. N.A. Semashko

The purpose of the study is to evaluate the symptomatology of multiple sclerosis (MS) and to evaluate the immune status in patients with reactivation of persistent herpes viral infection (PHVI). Material and Methods. We examined 56 patients with definite multiple sclerosis (MS) and 20 patients treated for other diseases of nervous system (radicu-iar syndrome caused by degenerative disease backbone) (comparison group). The MS patients were divided into 2 groups: patients without reactivation of PHVI (typical MS) and patients with reactivation of PHVI (virus-associated MS). The PHVI reactivation was registered in the case of presence of the appropriate clinical features and it was also verified by serological methods (ELISA). The symptomatology of MS was evaluated according to FS and EDSS scales. We performed the study of cell and humoral adaptive immunity. Results. Patients with reactivation of PHVI had more significant neurological symptomatology, more frequent relapses of MS, a higher speed of MS progression compared with typical MS patients. The immune status features in virus-associated MS patients can be estimated as a combination of secondary immunodeficiency (T-cell mediated) and active autoimmune process (the activation of B-cell component). Conclusion. It was revealed more significant neurological symptomatology, severer MS course and markers of secondary immunodeficiency in MS patients with reactivation of PHVI.

1 Goncharova ZA. Clinical and epidemiological peculiarities of multiple sclerosis in Rostov Region. Medical Herald of the South of Russia 2010; (1): 62-66
2 Munger KL, Levin LI, O'Reilly EJ, et al. Anti-Epstein-Barr virus antibodies as serological markers of multiple sclerosis: a prospective study among United States military personnel. Mult Scler 2011; 17 (10): 1185-1193. DOI: 10.1177/1352458511408991
3 Buljevac D, van Doornum GJ, Flach HZ, et al. Epstein-Barr virus and disease activity in multiple sclerosis. J Neurol Neurosurg Psychiatry 2005 Oct; 76 (10): 1377-1381
4 Kvistad S, MyhrKM, Holmmy T, et al. Antibodies to Epstein-Barr virus and MRI disease activity in multiple sclerosis. Mult Scler 2014 Dec; 20 (14): 1833-40. DOI: 10.1177/1352458514533843
5 Lublin FD. New multiple sclerosis phenotypic classification. EurNeurol2014;72(Suppl 1): 1-5. DOI: 10.1159/000367614
6 Belikova EA, Ivanova GF. The modern conceptions of herpetic infection. Lekarstvenny vestnik 2015; 9 (3): 22-27
7 Goleva OV, Murina EA, OsipovaZA. Newapproachestothe diagnosis of combined herpes viral infections in viral encephalitis in children. In: VI Baltic Congress on Pediatric Neurology: digest of theses of the congress. St. Petersburg: Saint Petersburg social organization «Chelovek i ego zdorov'e», 2016; p. 101
8 Grimbacher В, Warnatz К, Yong PFK, et al. The crossroads of autoimmunity and immunodeficiency: Lessons from polygenic traits and monogenic defects. J Allergy Clin Immunol 2016; 137 (1): 3-17. DOI: 10.1016/j.jaci.2015.11.004
9 Andreeva II, Sizyakina LP, Goncharova ZA. Inversion of homeostatic properties of immune system in multiple sclerosis. Medical Herald of the South of Russia 2016; (2): 23-27.

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