Saratov JOURNAL of Medical and Scientific Research

Peculiarities of clinical course of gastroesophageal reflux disease in patients with type 2 diabetes and obesity

Year: 2017, volume 13 Issue: №4 Pages: 809-812
Heading: Internal Diseases Article type: Original article
Authors: Andreeva E.l.
Organization: Stavropol State Medical University

Aim: to study the clinical course of gastroesophageal reflux disease (GERD) in patients with type 2 diabetes and evaluation of the parameters of the esophagus 24-hour pH-metry. Material and Methods. In the examination of patients with GERD, three groups of patients were selected for 50 people each. The first group includes patients with GERD with combined course of obesity and type 2 diabetes (mean age 54.6±2.73 year; 32 females and 18 males). The second group included patients with GERD against obesity (mean age 42.3±2.11 year; 30 females and 20 males). The control group consisted of patients with GERD without excess body weight and concomitant pathology (average age43.6±2.11 year; 29 females and 21 males). In addition to collecting complaints and anamnesis, the patients and the control group underwent a 24-hour pH-metric study of the esophagus according to a conventional method. Results. Patients suffering from GERD in the background of type 2 diabetes have a clinically asymptomatic or asymptomatic course; there is a significant increase in the daily pH-metry, indicating a more pronounced nature of the changes. Conclusion. Patients suffering from GERD in the background of type 2 diabetes require a comprehensive examination of the upper digestive tract to identify GERD, even if there are no complaints characteristic of the disease.

1. Ivashkin VT, Lapina TL, eds. Gastroenterologiya: Nat-sional'noe rukovodstvo: Kratkoe izdanie. M.: GEOTAR-Media, 2011; p. 86-99
2. Lazebnik LB, Masharova АА, Bordin DS. Results of a mul-ticentre study "Epidemiology of gastroesophageal reflux disease in Russia" (MEGRE). Therapeutic archive 2011; 1: 45-50
3. Dedov II, Mel'nichenko GA, Fadeev VV. Endocrinology. M.: GEOTAR-Media, 2009; 432 p.
4. Zvenigorodskaya LA, Bondarenko EYu, Churikova AA, Mishchenkova TV. Gastroesophageal reflux disease in patients with obesity (clinic, diagnosis, treatment): Methodical recommendations. M., 2011; 13 p.
5. Lazebnik LB, Zvenigorodskaya LA. Metabolic syndrome and digestive system. M.: Anakharsis, 2009; 184 p.
6. Maev IV. Dangerous comorbidity: a clinical presentation of а patient with obesity: Effective pharmacotherapy. Gastroenterology 2014; (3): 58-60
7. Zvenigorodskaya LA, Khomeriki SG, Bondarenko EYu. GERD for obesity: clinical, functional and morphological features, approaches to therapy. Vestnik Semeynoy Mediciny 2014; (3)
8. Guo F, Garvey WT. Development of a Weighted Car-diometabolic Disease Staging (CMDS) System for the Prediction of Future Diabetes. The Journal of Clinical Endocrinology 2015; 100 (10): 3871-3877
9. Livzan MA, Lapteva IV, KrolevetsTS, Kiselev IE. Features of the course of GERD associated with obesity and overweight. Therapeutic archive 2016; (2): 21-27
10. Pasechnikov VD, Pasechnikov DV Modern ideas about the pathogenesis of gastroesophageal reflux disease: News of Medicine and Pharmacy. Gastroenterology 2011; (382)
11. Zvenigorodskaya LA, Bondarenko EYu, Khomeriki SG. Clinical and morphological features of gastroesophageal reflux disease in patients with abdominal obesity. Consilium medicum 2010; 12 (8): 5-10
12. Guo F, Moellering DR, Garvey WT. The progression of cardiometabolic disease: validation of a new cardiometabolic disease staging system applicable to obesity. Obesity 2014; 22 (1): 110-118
13. Usanova lYu, Kozlova NM, Lyakh GP Features of the three-hour pH-metry in young patients with GERD and excessive body weight. Siberian Medical Journal 2013; (4): 79-82.

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