Evaluation of the wound healing capacity of the gel form of the preparation "Mellisol" on the model of experimental planar wounds
Year: 2017, volume 13 Issue: №3 Pages: 635-640
Heading: Dermatovenerology Article type: Original article
Authors: Myl'nikov A.M., Nechaeva O.V., Zayarskiy D.A., Bespalova N.V., Mudrak D.A., Navolokin N.A.
Organization: Saratov State Medical University, Yuri Gagarin State Technical University of Saratov
Heading: Dermatovenerology Article type: Original article
Authors: Myl'nikov A.M., Nechaeva O.V., Zayarskiy D.A., Bespalova N.V., Mudrak D.A., Navolokin N.A.
Organization: Saratov State Medical University, Yuri Gagarin State Technical University of Saratov
Summary:
Objective: to study the wound healing activity of the gel form of the "Mellisol" preparation containing nanoaggregates of flavonoids stabilized with polyazolidine ammonium modified with iodine hydrate ions on a model of experimental planar wounds of rats. Material and Methods. An investigation of the wound healing activity of the gel form of the "Mellisol" preparation was carried out in vivo in 18 white laboratory rats of the Wistar line. Simulation of experimental planar wounds was performed according to the standard procedure described in the preclinical testing manual. Results. In the course of the studies, it was established that a statistically significant (p=0.045) acceleration of healing on the 12th day of the experiment occurred in animals of the experimental group on whose wounds the gel form of the cosmetic means "Mellisol" was applied, and the complete healing of the wound defect occurred on the 21st day after operation. Conclusion. The gel form of the preparation "Mellisol" is characterized by a high level of antimicrobial and regenerative activity reliably reducing the healing time for planar wounds without the development of microbial complications.
Keywords: antimicrobial activity, cosmetic product "Mellisol", planar wounds , wound healing activity
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