Saratov JOURNAL of Medical and Scientific Research

Analysis of the genes polymorphisms distribution of the MMP1, XRCC1, HFE (2), GSTT in patients with non-neoplastic melanin hyperpigmentation

Year: 2017, volume 13 Issue: №3 Pages: 590-594
Heading: Dermatovenerology Article type: Original article
Authors: Ikonnikova EV, Kruglova LS, Shatokhina EA, Talybova AM.
Organization: Central State Medical Academy of the ADP of the Russian Federation

Objective: to study the factors of increased risk of hyperpigmentation, with the polymorphism of MMP1, XRCC1, HFE (2), GSTT genes and analysis of their association in patients with various clinical forms of non-neoplastic melanin hyperpigmentation. Material and methods. The study included 38 patients with hyperpigmentation (melasma / chlo-asma, post-traumatic/ post-inflammatory hyperpigmentation, solar lentigo). All patients were underwent buccal swabs with sterile cotton buds to take the material for the study. All patients were underwent genetic analysis of polymorphism of HFE (2), XRCC1, MMP1, and GSTT genes by genotyping single-nucleotide substitutions. Results. In patients with melasma / chloasma, the high value of the alleles cipher of MMP1, XRCC1, and GSTT genes was noted, while the cipher of HFE (rs1799945) and HFE (rs1800562) allele index showed average values. In patients with post-traumatic / post-inflammatory pigmentation, the high value ofthe alleles cipher of MMP1, HFE (rs1799945) and HFE (rs1800562), GSTT genes was noted, while XRCC1 allele cipher showed average values. In patients with solar lentigo, the high value ofthe alleles cipher of MMP1, XRCC1, and GSTT genes was noted, while the cipher of HFE (rs1799945) and HFE (rs1800562) allele index showed average values. Conclusion. Was revealed the similarity ofthe results of genetic research in patients with melasma / chloasma and in patients with solar lentigo.

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