Saratov JOURNAL of Medical and Scientific Research

Dynamics of angiogenesis and inflammation biomarkers in patients with urolithic disease with obstructive uropathy

Year: 2017, volume 13 Issue: №3 Pages:
Heading: Urology Article type: Original article
Authors: Popkov V.M., Zakharova N.B., Ponukalin A.N., Polozov A.B., Khotko D.N., Khotko A.l., Spirin P.V.
Organization: Scientific Research Institute of Traumatology Orthopedics and Neurosurgery of Saratov State Medical University n.a. V.I. Razumovsky

Purpose: to establish the nature of changes in markers of angiogenesis and inflammation in the blood serum and urine in patients with obstruction of the ureteropelvic segment or upper third of the ureter by ureteral stones in different terms of the kidney drainage. Material and Methods. 53 patients with urolithiasis have been examined. The main group consisted of 33 patients with concrements of the upper third of the ureter or renal pelvis-ureteral segment with pres- ent obstructive uropathy. The comparison group consisted of 20 patients with calculi of the kidney without symptoms of obstruction. In the main group patients underwent drainage of the kidney by percutaneous-nephrostomy puncture. Results. Patients of the main group revealed a significant increase in the levels of markers of angiogenesis and inflammation before the kidney drainage. The level of MCP-1 correlated with the level of serum creatinine. In the process of drainage the levels of these markers were decreased as a result of increased GFR. Determination of the concentration of urinary VEGF, IL-8 and MCP-1 in patients may have clinical value in personalized management of patients with obstructive uropathy to determine the optimal terms of the second stage of the surgical intervention. Conclusion. Determination of markers of inflammation and angiogenesis in the urine of patients in conjunction with assessment of renal function by creatinine level is important for determining the term of kidney drainage.

1. Ucero AC. Goncalves S, et al. Obstructive renal injury: from fluid mechanics to molecular cell biology. Open Access Journal of Urology 2010; (2): 41-55
2. Dendooven A, Ishola DA Jr, et al. Oxidative stress in obstructive nephropathy. Int J Exp Path 2011; (92): 202-210
3. Hegarty N, Young L, O'Neill A, et al. Endothelin in unilateral ureteral obstruction: vascular and cellular effects. J Urol 2003; (169): 740-744
4. Russo RC, Garcia CC, Teixeira MM, et al. The CXCL8/IL-8 chemokine family and its receptors in inflammatory diseases Expert Rev Clin Immunol 2014; 10 (5): 593-619
5. Morozov DA, Morozova OL, Zakharova NB, Lakomova DYu. Modern principles of diagnostics and prognosis of chronic obstructive pyelonephritis in children. Urology 2013; (3): 68-73
6. Popkov VM, Dolgov АВ, Zaharova NB, et al. Urinary biomarkers in acute pyelonephritis. Saratov Journal of Medical Scientific Research 2013; 9(1): 110-115
7. Ferrara N. Vascular endothelial growth factor: basic science and clinical progress. Endocr Rev 2004; (25): 581-611
8. Grenda R, Wuhl E, Litwin M. Urinary excretion of endothelin-1 (ET-1), transforming growth factor-M (TGF-M) and vascular endothelial growth factor (VEGF165) in pediatric chronic kidney diseases: results of the ESCAPE trial. Nephrol Dial Transplant 2007; (22): 3487-3494
9. Burt LE, Forbes MS, Thornhill BA, et al. Renal vascular endothelial growth factor in neonatal obstructive nephropathy. II: Exogenous VEGF. Am J Physiol Renal Physiol 2007; 292 (1): 168-174
10. Glyibochko PV, Zaharova NB, Ponukalin AN, et al. Diagnostic value of the increased levels of proinflammatory cytokines in the urine during exacerbation of chronic calculous pyelonephritis. Saratov Journal of Medical Scientific Research 2011; 7 (S2): 143
11. Rusakov АА. Markers of inflammation, sclerosis and regeneration of renal tissue in unilateral obstructive uropathy in children before and after surgical restoration of urodynamics: PhD diss. Moscow, 2016; 119 p.
12. Bobkova IN. Clinical significance of determination of urinary markers of endothelial dysfunction and angiogenesis factors in the evaluation of tubulointerstitial fibrosis in chronic glomerulonephritis. Therapeutic Archiv 2007; (6): 10-15
13. Roy Н, Bhardway S, Yla — Hertuala S. Biology of endothelial growth factor. FEBS Lett 2006; (580): 2879-2887
14. Zaharova NB, DolgovAB, Inozemtseva ND, Blyumberg Bl. Biomarkers of infectiously-inflammatory diseases of buds and urinoexcretory ways. Spravochnik-zaveduyushcego-kdl 2013; 2: 48-59.

2017_03_527-532.pdf378.73 KB

No votes yet