Saratov JOURNAL of Medical and Scientific Research

ОСТ investigation of influence of cement kiln dust and keratoprotectoral medication on the cornea structure.

Year: 2017, volume 13 Issue: №2 Pages: 400-406
Heading: Ophtalmology Article type: Original article
Authors: Kalmykov R.V., Popova D.V., Kamenskikh T.G., Genina E.A., Tuchin V.V., Bashkatov A.N.
Organization: National Research Tomsk State University, Saratov State Medical University, Saratov state university
Summary:

The research goal: in vitro study of cornea permeability at the action of cement kiln dust and keratoprotectoral medication. Materials and Methods. Experimental studies were carried out with twenty eyes often rabbits. The measurements were performed using ОСТ system OCP930SR 022 (Thorlabs, USA). Results. ОСТ tomography was used to monitor the attenuation coefficient of the cornea in vitro during the permeability of cement kiln dust and keratoprotector Systein Ultra. The permeability coefficients of the cornea for water, cement dust and keratoprotector were measured. A computer model was developed that allowed one to analyze the diffusion of these substances in the eye cornea. Conclusion. It is shown: 1) cement dust falling on the eye cornea caused pronounced dehydration of the tissue (thickness decreasing) and led to the increase in the coefficient of light attenuation, which in the conditions of cement production could affect the deterioration of the eyesight of workers; 2) the application of the keratoprotector on the eye cornea when exposed by cement dust, slowed significantly the dehydration process and did not cause the increase in the light attenuation coefficient, which characterized the stabilization of visual functions in cement production workers. In this case, the keratoprotector itself did not cause dehydration and led to the decrease in the light attenuation coefficient, which could allow it to be used for a long time in the order to protect the organ of vision from the negative effects of cement dust.

Bibliography:
1. Kalmykov RV, Istomin AV, Kamenskikh TG, et al. Pathology of the anterior eye in workers of cement production. Zdorov'e naselenija i sreda obitanija 2015; 4 (265): 13-17
2. Genina ЕА, Bashkatov AN, Kamenskikh ID, et al. ОСТ/ LCT monitoring the drug effect on the human cornea structure in vivo. Journal of Biomedical Photonics & Engineering 2015; (1): 77-80
3. Leonard DW, Meek KM. Refractive indices of the collagen fibrils and extrafibrillar material of the corneal stroma. Biophysical J 1997; (72): 1382-1387
4. Reshetnikov MV, Gejdzher DF, Lazareva VF, Sheshnev AS. Ecologo-geochemical investigation of soils and assessment of dust level in the territory of Volsk city (in a zone of influence of JSC Volskcement). Izvestiya of Saratov University 2011; 2 (1): 51-57
5. Kolomeets Ml, L'vov AV, Sevrikov VV. Research of chemical composition of dust of cement productions. Optimizacija proizvodstvennyh processov 2010; (12): 216-221
6. Kalmykov RV, Kamenskikh TG. Preparations based on hydroxypropyl-guar in the treatment of the «dry eye» syndrome in patients involved in cement manufacture. Messenger Bashkir State Medical University, 2016; (1): 48-52
7. Systane Ultra. URL: http://www.systane.ru/product-ingredients/systane-ultra-lubricating-eye-drops
8. Lee P, Gao W, Zhang X. Performance of single-scattering model versus multiple-scattering model in the determination of optical properties of biological tissue with optical coherence tomography. Appl Opt 2010; 49 (18): 3538-3544
9. Yust BG, Minum LC, Sardar DK. Optical absorption and scattering of bovine cornea, lens, and retina in the near-infrared region. Lasers Med Sci 2012; 27 (2): 413-422
10. Kamenskikh TG, Bashkatov AN, Tuchin VV, Genina EA. Clinical-experimental basing of the usage of Cortexin in treatment of the partial optic atrophy. Klinicheskaja Oftal'mologija 2006; 7 (4): 147-150
11. Kamenskikh TG, Bashkatov AN, Tuchin VV, Genina EA. Experimental grounds of the usage of Retinalamin in the treatment of the partial optic atrophy. Saratov Journal of Medical Scientific Research 2007; 3 (1): 77-79
12. McCally RL, Farrell RA. Light scattering from cornea and corneal transparency. In: Masters B, ed. Noninvasive Diagnostic Techniques in Ophthalmology. New York: Springer-Verlag; 1990; p. 189-210
13. Pircher M, Gotzinger E, Leitgeb R, et al. Measurement and imaging of water concentration in human cornea with differential absorption optical coherence tomography. Optics Express 2003; 11 (18): 2190-2197
14. Bohren CF, Huffman DR. Absorption and scattering of light by small particles. New York: John Willey & Sons Inc., 1983, 530 p.
15. Bandi BD. Basic Optimization methods. School of Mathematical Sciences. University of Bradford: Edward Arnold Limited, 41 Bedford Square, London WC1B 3DQ, 1984.

AttachmentSize
2017_02-1_400-406.pdf577.26 KB

No votes yet