Saratov JOURNAL of Medical and Scientific Research

2016, volume 12

The microecological and immunological problems of persistention of Helicobacter pylori

Year: 2016, volume 12 Issue: №1 Pages: 19-26
Heading: Microbiology Article type: Review
Authors: Belova O.L., Schelekhova T.V., Belova I.M.
Organization: Saratov State Medical University
Summary:

The interrelation of persistence of Helicobacter pylori in stomach with innate and adaptive immunity of human has been discussed. The analysis of the mechanisms of immunological recognition of the antigens of this microorganism and response to them has been performed. It has been considered, that the development and course of gastritis and ulcer in human with Helicobacter pylori stipulate for inadequate reactions of immune system and common reactivity by the individual organism in presence of Helicobacter pylori in mucus of stomach.

Keywords: gastritis, Helicobacter pylori, immune recognition, persistence

Anatomy of sphenoid part of middle cerebral artery in adults

Year: 2016, volume 12 Issue: №1 Pages: 15-18
Heading: Macro- and Micromorphology Article type: Review
Authors: Fomkina О.А., Nikolenko V.N., Gladilin Yu.A.
Organization: First Moscow State Medical University n.a. I.M. Sechenov, Saratov State Medical University
Summary:

The information about anatomy of middle cerebral artery in adults has been summarized on the basis of data analysis of domestic and foreign scientific literature. Material concerning options for arteries discharge, area of blood supply, major anomalies and size characteristics (outer diameter, wall thickness, lumen diameter) has been represented in this work.

Keywords: cerebral artery, sphenoid part of the middle cerebral artery

Immuno-morphological features of the rat's thymus at the experimental administration of cytostatics

Year: 2016, volume 12 Issue: №1 Pages: 12-14
Heading: Macro- and Micromorphology Article type: Original article
Authors: Lebedinskaya Е.А., Lebedinskaya O.V., Godovalov А.Р., Prokudin V.S.
Organization: Perm State University of Medicine n.a. academician E.A. Vagner
Summary:

The aim is to identify the changes in the rat's thymus structure under immunosuppression induced injection of cyclophosphamide with the use of morpho-histochemical and morphometric methods. Material and methods. For immunosuppression of animals cyclophosphamide at 100mg/kg body weight 4-fold with a 24-hour interval was injected intraperitoneally. Thymus serial paraffin sections were stained with hematoxylin and eosin, azure ll-eosin, methyl green pyronin according to Brachet, and periodic acid-Schiff before and after treatment with amylase. Results. Significant morphological changes in the thymus at rats with injection of cyclophosphamide were established. Morpho-histochemical changes in the rat's thymus characterize the immunosuppressive state of the experimental animals' organisms. Conclusion. It was shown the necessity of complex morphological studies including macrophage activity and characteristics of the subpopulation of mononuclear leukocytes spleen, changes in the structure of hematopoietic and lymphoid organs under immunosuppression induced by cyclophosphamide.

Keywords: cytostatics, experimental animals, induced immunosuppression, morpho-histochemical, thymus

Features of the prevalence of injecting drug use in the Republic of Belarus

Year: 2016, volume 12 Issue: №1 Pages: 7-11
Heading: Health Service Organization Article type: Original article
Authors: Lelevich V.V., Vinitskaya A.G., Sarana Y.V., Tishchenko E.M.
Organization: Grodno State Medical University
Summary:

Aim: to analyze the situation with injecting drug use in the Republic of Belarus during the period 2000-2014. Material and Methods. The analysis of the official data on the psychoactive substances' abusers, listed in the Narcological Register of the Ministry of Health in 2000-2014. Results. Over last 15 years the number of registered drug abusers increased three times, whereas the number of injecting drug users (IDUs) increased 2,2 times. The majority of recorded IDUs abused opium-based drugs and only 3% of them injected amphetamine-type stimulants. The increase in the number of recorded persons, who abuse synthetic opioids and analogues of well-known drugs, was noted during the last ten years. Conclusion. The data obtained indicate necessity of the studies on IDUs, and might be useful for working up preventive measures to restrain the spread of drug addiction.

Keywords: injecting drug users (IDUs), Narcological Register, psychoactive substances