№3, 2016, volume 12

The review presents research materials dealing with sexual dimorphism in the efficacy of botulinum toxin dosing. The differences in the structure of muscle and skeleton of male and female faces are presented. We have also considered the features of implementation of injection techniques, depending on gender.

This review presents the data from published literatures and the research works conducted by the authors about mechanisms of action of botulinum toxin and its use in the practical medicine (particularly in dermatology and cosmetology). Indications and contraindications of botulinum toxin use in cosmetology are also considered in this work.

There is an overview of the literature is carried out reflecting the use of platelet-rich plasma in various fields of medicine, methods of preparation and its use in dermatology.

This review summarizes the literature, specifically describing etiology, pathogenesis, classification and inheritance of ichthyosiform dermatoses. A case of ichthyosis vulgaris inherited in three generations of a family is described.

Relative importance of the current issue is based on rare occurrence of this dermatosis, its genetic predisposition and occurrence in early childhood. The Goldenhar syndrome diagnosing is a difficult task and causes difficulty in selecting treatment, due to large number of clinical syndromes presenting with facial deformities and the inability to quickly identify concomitant signs of damage to other organs and systems.

There a case of a rare form of congenital localized keratoderma is presented. The described case shows an inherited congenital localized keratoderma in an autosomal dominant pattern, associated with the fungal infection. Positive

Pityriasis rubra pilaris (Devergie's disease) is a rare chronic papulosquamous skin disease, it is of unknown etiology, leading to palmoplantar keratoderma, erythroderma and ectropion. Due to its rarity and difficulty in differentiating it with psoriasis, we are presenting our own observations and diagnostcis. We present a patient with a classical type 1 iasis rubra pilaris of a type I, whose condition improved significantly after treatment with systemic aromatic retinoids.

One of the most common forms of eczema is microbial eczema constituting 12-27% of all the cases of eczema. Application of nanotechnology in the field of medicine, including dermatology and cosmetology continues to increase. An example of innovation, demonstrating the results of research within the chemical technology and practical dermatology and cosmetology is a cosmetic product based on nanostructured systems "core — shell", which is an aqueous dispersion of nanoscale flavonoid "cores", derived from natural propolis which are stabilized by polyelectrolyte "shell". The purpose of this work is to conduct primary research on cosmetic product "Mellisol" on the basis of composite structures "core — shell" stabilized by polyelectrolyte membrane, for its application in the complex therapy in the treatment of microbial eczema. Description of these cases under clinical observation shows high efficacy and safety of cosmetic product "Mellisol" in the treatment of patients with microbial eczema in its acute phase.

The Aim of the study: to define the characteristics of the current treatment of psoriatic arthritis in the settings of specialized medical care in a hospital, based on pharmacoepidemiological study, to optimize the treatment of such patients. Material and Methods. A retrospective pharmacoepidemiological study is based on an analysis of medical records of hospitalized patients rheumatology department requesting assistance in the period from January 2016 to April 2016. Result. As a part of basic anti-inflammatory therapy of psoriatic arthritis, methotrexate was used in 67% patients, sulfasalazine in 25% patients, and cyclosporine and D-penicillamine in 4% patients. Genetically engineered biologic drugs (GEBD) were not used. The anti-inflammatory therapy in hospital was carried out with glucocorticosteroids in 33% patients, with non-steroidal anti-inflammatory drugs (NSAIDs) in 20% cases and in 47% cases a combination of both was used. Gastroprotective therapy was given to all patients receiving corticosteroids and NSAIDs. Conclusion. The study shows that, the treatment of psoriatic arthritis meets the current recommendations, although there are problems associated with excessive use of corticosteroids and the lack of GEBD.

The new understanding of the disease requires the development of modern methods in the management strategy of atopic dermatitis. Individual approach to educate patients with use of modern gadgets in addition to the standard methods of treatment is a relatively new concept in dermatology. Educational programs for atopic dermatitis have a positive impact on the severity of dermatoses, as well as on psychological status.