Saratov JOURNAL of Medical and Scientific Research

Biomechanical modelling of cerebral arteries at different variants of configuration of intracranial arteries of vertebrobasilar system

Year: 2016, volume 12 Issue: №2 Pages: 118-127
Heading: Macro- and Micromorphology Article type: Original article
Authors: Fomkina О.А., Ivanov D.V., Kirillova I.V., Nikolenko V.N.
Organization: Saratov State Medical University, Saratov state university
Summary:

The purpose is to consider the biomechanical modelling of cerebral arteries at different structural variants of intracranial arteries of vertebrobasilar system. Material and methods. By means of the system of the final and element analysis ANSYS on the basis of data on geometry, morphometricand biomechanical properties of cerebral arteries their biomechanical models have been constructed. On the received models for 9 structural variants of intracranial arteries of vertebrobasilar system, haemodynamic parameters and parameters of the intense deformed condition of walls of arteries have been analyzed. Results. The most frequent variant of a configuration of intracranial department of vertebrobasilar system is the combination of average in size of angles of connection of vertebrata and bifurcation of basilar arteries. Such option occurs in 49% of cases. More rare variant (1,5% of cases) with the narrow angles of connection of vertebrata and bifurcations of basilar arteries has been observed. The design of intracranial arteries of vertebrabasi-lar system exerts an impact on distribution of bloodflow and effective tension in a vascular wall of back brain arteries. Conclusion. According to the study it has been determined that the constructed individual biomechanical models may provide information on some parameters of haemodynamics and the intense deformed condition of a vascular wall which causes the development of atherosclerosis and intracranial aneurisms.

Bibliography:
1. Bolshakov O.P. A modeling method in applied anatomic and pilot studies. Clinical anatomy and experimental surgery: Year-book of the Russian association of clinical anatomists 2001; 1: 13-16
2. Frolov S.V., Sindeev S.V., Lipsh D., Balasso A. Mathematical modeling of the movement of blood in the field of bifurcation of a bazilyarny artery. Bulletin of the Tambov state technical university 2014; 20 (1): 50-58
3. Watton PN, Ventikos Y, Holzapfel GA. Modelling the growth and stabilization of cerebral aneurysms. Mathematical Medicine and Biology 2009; 26: 133-164
4. Ivanov D., Dol A, Pavlova O., Aristambekova A. Modeling of human circle of Willis with and without aneurisms. Acta of Bioengineering and Biomechanics 2014; 16(2): 121-129
5. Ren Y, Chen Q, Li Z. A 3D numerical study of the collateral capacity of the circle of Willis with anatomical variation in the posterior circulation. BioMedical Engineering OnLine 2015; (14) (Suppl. 1): 11
6. Bui A, ManassenR, SutalolD, Liffman K. Multiscale vodeling of cerebral blood flow. In: Sevent International Conference on CFD in the Minerals and Process Industries. Australia, Melbourne: Csiro, 2009; p. 145-147
7. Berg P, Stucht D, Janiga G. et al. Cerebral blood flow in a healthy Circle of Wllis and two intracranial aneurysms: computational fluid dynamics versus four-dimensional phase-contrast magnetic resonance imaging. Journal of Biomechanical Engineering 2014; 136: DOI: 10.1115/1.4026108
8. Fomkina O.A., Nikolenko V.N. Morphometric parameters of arteries of a brain of adults of 35-60 years. Morphological sheets 2015; 23 (2): 96-104
9. Ivanov D.V., Fomkina O.A. Determination of mechanical properties of arteries of a villiziyevy polygon. Russian magazine of biomechanics 2008; 12 (4): 75-83
10. Baryshev А.А., Aranovich V.M., Sidorenko O.V. Three-dimensional modeling of bone tissues of the person with use of a computer tomography. In: Methods of computer diagnostics in biology and medicine of 2009: materials of annual All-Russian scientific workshop. Saratov, 2009; p. 80-83
11. Sforza DC. Hemodynamics of cerebral aneurysms. Annu Rev Fluid Mech 2009; 41: 91-107
12. Sheffield E.A., Weller R.O. Age changes in cerebral artery bifurcations and the pathogenesis of berry aneurisms. J of Neurology Sciences 1980; 46: 341-352
13. Malek A.M., Alper S.L., Izumo S. Hemodynamic shear stress and its role in atherosclerosis. J of the American Medical Association 1999; 282: 2035-2042.

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