Correlation between the frequency of the infectious complications of abdominal surgery and the level of immune response to the surgical trauma
Year: 2013, volume 9 Issue: №4 Pages: 954-957
Heading: Surgery Article type: Original article
Authors: Korsakov I.N., Voskanyan S.E., Naydenov E.V., Timashkov D.A., Chervov A.Yu., Volkov A.A., Bolshakov M.S.
Organization: State Scientific Research Center n.a. A.I. Burnasyan — Federal Medical Biophysical Center of Federal Medical Biological Agency
Heading: Surgery Article type: Original article
Authors: Korsakov I.N., Voskanyan S.E., Naydenov E.V., Timashkov D.A., Chervov A.Yu., Volkov A.A., Bolshakov M.S.
Organization: State Scientific Research Center n.a. A.I. Burnasyan — Federal Medical Biophysical Center of Federal Medical Biological Agency
Summary:
Aim: to evaluate the correlations between the frequency of the infectious complications of abdominal surgery and the level of immune response to the surgery. Material and methods. The study has been conducted on 53 patients, who were undergone to pancreaticoduodenal resection with lymphadenectomy. Concentrations of interleukin-4 (IL-4) and interleukin-8 (IL-8) in blood serum were studied. Results. The concentrations of IL-8 were higher in patients with complications compared to those without complications. No statistically significant differences in the concentrations of IL-4 were revealed between the studied groups of patients. Conclusion. Concentrations of pro-and anti-inflammatory cytokines can be used to assess the risk of postoperative complications.
Bibliography:
1. Hildebrand R, Pape H.C., Krettek С The importance of cytokines in the posttraumatic inflammatory reaction // Unfallchirurg. 2005. Vol. 108. P. 793-803;
2. Inflammatory response after abdominal surgery / B. Sido, J. R. Teklote, M. Hartel [et al.] // Best Pract. Res. Clin. Anaesthesiol. 2004. Vol. 18. P. 439-454;
3. Bobocea A. C, Trandafir В., Bolca C, Cordos I. Minimally invasive surgery in cancer: immunological response // Chirurgia (Bucur). 2012. Vol. 107. P. 154-157;
4. Anesthetic technique and the cytokine and matrix metalloproteinase response to primary breast cancer surgery/C.A. Deegan, D. Murray, P. Doran [et al.] // Reg. Anesth. Pain. Med. 2010. Vol. 3. P. 490-495;
5. Nicholson G., Hall G.M. Effects of anaesthesia on the inflammatory response to injury // Curr. Opin. Anaesthesiol. 2011. Vol. 24. P. 370-374;
6. Kumpf O., Schumann R.R. Genetic variation in innate immunity pathways and their potential contribution to the SIRS/ CARS debate: evidence from human studies and animal models //J. Innate. Immun. 2010. Vol. 2. P. 381-394;
7. Do the changes in the serum levels of IL-2, IL-4, TNFalpha, and IL-6 reflect the inflammatory activity in the patients with post-ERCP pancreatitis? / G. Kilciler, U. Musabak, S. Bagci [et al.] // Clin. Dev. Immunol. 2008. Vol. 2008. 7 p.;
8. Fry D.E. Sepsis, systemic inflammatory response, and multiple organ dysfunction: the mystery continues // Am. Surg. 2012. Vol.78. P. 1-8.
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