Saratov JOURNAL of Medical and Scientific Research

Markers of systemic inflammatory response in coxarthrosis

Year: 2013, volume 9 Issue: №4 Pages: 679-683
Heading: Clinical Laboratory Diagnostics Article type: Original article
Authors: Korshunov G.V., Shakhmartova S.G., Puchinyan D.M.
Organization:
Summary:

Objective: to detect markers of the systemic inflammatory response syndrome in patients with coxarthrosis by means of assessment of the status of the hemostasis system, endothelium function and inflammation intensity. Material and Methods. The indices of the plasmatic hemostasis, levels of VCAM-1, ICAM-1, ELAM-1, VEGF-A, neop-terin were analyzed. Results. It has been found that among the patients with hip coxarthrosis a group of patients (47%) with endothelium dysfunction, cellular immunity activation, a high content of Soluble Fibrin Monomer Complex and D-dimers and a group of patients (53%) without any abnormalities in these parameters should be differentiated. Conclusion. Among the patients with hip coxarthrosis a group with signs of a systemic inflammatory response syndrome (occurrence of endothelium dysfunction, cellular immunity activation, a high content of Soluble Fibrin Monomer Complex and D-dimers) and a group of patients with reference values of these parameters can be determined. The markers of the systemic inflammatory response syndrome in cases with hip osteoarthrosis are Soluble Fibrin Monomer Complex and D-dimers, high levels of intercellular adhesion molecule-1 (slCAM-1), vascular cell adhesion molecule-2 (sVCAM-1), cell adhesion E-selectin-1 (ELAM-1) and Neopterin (Np).

Bibliography:
1. Folomeeva О.М., Jerdes Sh.F., Nasonova V.A. Revma-ticheskie zabolevanija u naselenija Rossijskoj Federacii v na-chale XXI veka //Terapevticheskij arhiv. 2007. № 12. S. 5-12; 2. Makacarija A.D., Bicadze V.O., Akin'shina S. V. Sindrom sistemnogo vospalitel'nogo otveta v akusherstve. M., 2006. 448 s.; 3. Hoffmann G., Wirleitner В., Fuchs D. Potential role of immune system activation-associated production of neopterin derivatives in humans// Inflamm. res. 2003. Vol. 52. P. 313-321; 4. Petrishhev N.N., Vlasov ID. Disfunkcija jendotelija: Prichiny, mehanizmy. Farmako-logicheskaja korrekcija. SPb., 2003. 184 s.; 5. Molekuljarnye markery aktivacii gemostaza posle jendo-protezirovanija krupnyh sus-tavov na fone antitromboticheskoj profilaktiki nizkomolekuljarnym geparinom / I.P. Antropova, A.V Osipenko, E.V Rejno [i dr.] // Materialy II s#ezda travma-tologov-ortopedov Ural'skogo federal'nogo okruga. Kurgan, 2008. S. 126-127; 6. Orel E.B., Vinogradov V P., Andreeva A.S., Vasil'ev S. A. D-dimer — marker diagno-stiki, monitorirovanija i progno-zirovanija trombozov // Tromboz, gemostaz, reologija. 2012. № 4. S. 33-40; 7. Kuznik B.I. Kletochnye i molekuljarnye mehanizmy regul-jacii gemostaza v norme i pa-tologii. Chita: Jekspress-izdatel'st-vo, 2010. 832 s.; 8. Cvinger S. M., Govorin A.V, Alekseenko E.Ju. Markery jendotelial'noj disfunkcii pri osteoartroze // Dal'nevostochnyj medicinskij zhurnal. 2009. № 3. S. 9-11; 9. Sviridov E.A., Telegina ТА. Neopterin i ego vosstanovlen-nye formy: biologiche-skaja rol' i uchastie v kletochnom immu-nitete // Uspehi biologicheskoj himii. 2005. T. 45. S. 355-390. 10. Shevchenko O. P., Olefrienko G.A., Orlova O. V Neopterin. M., 2003. 64 s.; 11. Dmitrieva L.A. Rol' immunnyh i jendokrinnyh mehaniz-mov v patogeneze displasti-cheskogo koksartroza i zakonomer-nosti ih izmenenij pri jendoprotezirovanii tazobedrennogo sus-tava: dis. ... d-ra med. nauk. Chita, 2009. 43 s.

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