Saratov JOURNAL of Medical and Scientific Research

Molecular mechanisms of rosacea pathogenesis

Year: 2013, volume 9 Issue: №3 Pages: 561-565
Heading: Dermatovenerology Article type: Review
Authors: Davydova A.M., Bakulev A.L, Morrison A.M., Leonova M.A.
Organization: Saratov State Medical University

The article presents possible molecular mechanisms for rosacea pathogenesis from current domestic and foreign clinical observations and laboratory research: regulation and expression defects of antimicrobial peptides, vascular endothelial growth factor, the effect of serine proteases, oxidative stress, reactive oxygen species and ferritin on the occurrence and course of rosacea. New developments in molecular biology and genetics are advanced for researching the interaction of multiple factors involved in rosacea pathogenesis, as well as providing the bases for potentially new therapies.

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