№2, 2012, volume 8

Objective: To determine sensitive and objective criteria of nephrosclerosis by testing the levels of markers of inflammation (MCP-1), fibrogenesis (TGF-(31), renal parenchymal damage (collagen type IV, a-GST, тт-GST), angiogenesis (VEGF) in urine of children with vesicoureteral reflux (VUR). Materials and methods: 80 patients with different stages of VUR have been observed before and 6 months after treatment. Results: «Index of early renal damage» can be found as correlation between VEGF and collagen type IV concentration. Conclusion: Estimation of «index of early renal damage» could be included in pediatric practice for the control of urinary tract dysfunction in children with VUR

Objective: To improve the efficiency of surgical rehabilitation of patients with traumas, their effects. Materials and methods: Short-term and follow-up results of the surgical treatment of patients with traumas and their effects have been analyzed. Statistical research methods have been used. Results: the efficiency of medical technologies during the early rehabilitation of patients has been demonstrated. Conclusion: Adoption of the most efficient medical technologies of general surgical treatment and postoperative rehabilitation of patients with traumas and their effects in daily practice provides high-grade restoration of the extremity's function, shortening of treatment period, decrease in number of complications and invalidism

Purpose. The purpose is to study the reaction of homeostasis system in stable and in distraction llizarov transosseous ostesysnthesis of the limbs bones at experimental animals (dogs) in highland conditions. Material and Methods. 63 adult mongrels aged from 1 to 3 years with 10-20 kg body weight and 15 cm minimal length of tibia were included in the experiment. Open osteosotmy of tibial mid-shaft followed by Kirschner wires insertion through tibial bone and llizarov frame assembly comprising 3 or 4 rings was performed under IV anaesthesia at 3200 m altitude above sea level. In experimental group including 33 mongrels the distraction was performed on the 5th day after osteotomy by 1 mm rate divided into 4 times within 10 days but in control group comprising 30 dogs the distraction was not provided. Every 10 days after distraction blood samples were taken in both groups to examine coagulation; the samples were taken from subcutaneous lateral tibial vein, ex tempora mixing with 3,8% solution of sodium citrate at 9:1 ratio. Then the plasma was separated and examined biochemically according to the accepted standards. Results. We obtained the data witnessing activation of coagulation component of homeostatic system in stable osteosynthesis of the limb bones using llizarov fixator with simultaneous inhibition of fibrinolytic component. In distraction osteosynthesis hyper-coagulation trend in homeostasis system with simultaneous suppression of fibrinolytic blood activity is vividly defined within the entire experiment period. Conclusion. Transosseous distraction osteosynthesis in highland condition causes considerable shifts in the system of homeostasis with definite domination of coagulation component which promotes formation of pre-thrombotic condition. Limb segment lengthening on the background of pre-thrombotic condition increases the risk of thromboembolic complications in highland conditions and requires appropriate measures of prophylaxis

Provision of medical and social assistance to children at risk groups has been analyzed theoretically. Information of medical and social assistance to children in the city of Ryazan has been presented

Research objective: To estimate cytogenetic effect of dentures on the condition of buccal epithelium by means of the micronuclear test. Materials and methods: For this test the most convenient object of the research is nonkeratinized stratified epithelium which has been taken from 24 patients before prosthetics. Statistical data processing has been done by means of a package of statistical programs «Stadia». Results: The increase in frequency of occurrence of cells with micronuclei in buccal epithelium in patients after the prosthetics that testifies to stability disturbance of genetic material in the studied cells. Influence of fillings and dentures has been revealed. Conclusion: It allows to apply safe materials in stomatology, having reduced their side effects on an organism as a whole

The Research Objective: To study patients with prosthetic stomatitis, who use the removable laminar dentures. Materials: The consultations and treatment of 79 patients aged 47-65 years have been conducted. The patients have been divided into two clinical groups. The first clinical group (39 persons) with the performance of immediate prosthet-ics; the second control clinical group (40 persons) — the permanent dentures were produced without the preliminary instruction. Results: All the patients, having the laminar dentures without the preliminary use of immediate constructions of dentures, in spite of repeated correction of them, have had changes of dentures and transitory fold. Patients have been exposed to prosthetic stomatitis of different etiology (without trauma); the single-shot or multiple correction of dentures by the method of rebasing with using of cold cure plastics has been made. Conclusion: Structural and functional changes of dentition during the prosthetic stomatitis lead to disorders, associated by the mucositis. Use of the term of «prosthetic stomatitis» reflects etiological and pathogenetic component of changes in the denture-supporting tissues

Objective: To study clinical-morphological characteristics of parodontal diseases, markers of density of bone tissue and to define rational approaches to prosthetics of defects of dentitions in patients with colon diseases. Materials and methods: 55 patients with ulcerative colitis, even 80 with the syndrome of the irritable bowel syndrome with defects of dentitions, have been applied metallic, cement prostheses and having prostheses on the intraosseous of implants. Markers of bone metabolism in the blood serum and in the oral liquid, the proliferating activity of the epitheliocytes of periodontium have been evaluated according to the morphometric indices of the markers of the proliferation of ki-67, cyclein D1, the inhibitor of apoptosis of bcl-2 have been inspected. Results: Connection of intensity of periodontitis with the stage of colon disease has been stated. Metallic dental prostheses have been served as additional risk factors of development of parodontal diseases in patients with ulcerative colitis. Conclusion: The diagnostic value of the markers of proliferation has been determined in diagnostics of parodontal disease during the application of prostheses from different materials.

The fetus of a man develops in difficult conditions of mutual relations, both with an organism of mother, and with environment, and consequently protection and strengthening of health of children should be carried out taking into account health of mother, the way of life, place of living, course of pregnancy and delivery. The research goal is to reveal the factors which are predictors of physical development of newborn children and drawing up of prognostic models of anthropometric indicators at birth. Materials and methods: Survey of 220 newborns born in time and their mothers has been conducted. The anthropometry has included measurement of body weight, length, head and breast circles in children at birth. Results: The analysis of somatic, infectious, obstetric and gynecologic incidence of mothers of studied children, and also the course of pregnancy and delivery has been carried out. Conclusion: According to the data physical development of newborn children has been influenced by a number of factors. During the research work the prognostic models have been determined allowing to define the factors influencing physical intrauterine development of a child.

The article presents the results of research of physical development of children of infant and early age living in the territory of Engels Municipal Union. The purpose: To prove necessity of working out of regional standards of physical development of children under three years. Material and methods: Anthropometrical investigation of children under three years living in territory of Engels Municipal Union has been carried out. Results: Regional features of physical development of healthy children of region and discrepancy of centile tables of physical development estimation of children of infant and early age have been revealed. Conclusion: The received data have confirmed necessity of regional centile tables of physical development estimation of children.

Research objective: Study of anatomic features of neurovascular conflict predisposing to neuralgic status development. Materials: Among 200 patients with neuralgia of the trigeminal nerve (NTN), 12 persons taken to the clinic for treatment have been in the condition of neuralgic status (NS). Results: Among 130 patients with trigeminal nerve radix (TNR) conflict with one stem of superior cerebellar artery (SCA) status has been developed in 3 patients (2,15%). At TNR conflict with two stems of superior cerebellar artery (SCA) neuralgic status has been developed in 2 out of 32 persons (6,25%). Three patients out of 9 (33%) being in conflict to TNR where superior cerebellar artery participated from the ventral side and the superior petrosus vein from the dorsal side have been hospitalized with neuralgic status. Two patients (50%) with NS out of 4 with SCA conflict from the ventral side and anterior inferior cerebellar artery from the dorsal side have been hospitalized. Neurovascular conflict of trigeminal nerve radix with two stems of superior cerebellar artery in front and stem of anterior inferior cerebellar artery behind have been found in 6 persons, two of them have been hospitalized in the condition of neuralgic status (33%). The influence upon trigeminal nerve radix has been observed either from the ventral side or from the dorsal one in the rest of 19 patients. Neuralgic status has not been found. Conclusion: The development of neuralgic status is predisposed by the conflict of trigeminal nerve radix with several vessels simultaneously damaging its ventral and dorsal surfaces.