Saratov JOURNAL of Medical and Scientific Research

№2, 2012, volume 8

Assessment of the prevalence and severity of the pathological process in patients with acnes with the use of in vivo fuorescence diagnostics

Year: 2012, volume 8 Issue: №2 Pages: 668-671
Heading: Skin Diseases Article type: Original article
Authors: Utz S.R., Dolotov LE., Sinichkin U.P., Galkina E.M., Katkova I.O.
Organization: Saratov State Medical University, Saratov state university
Summary:

Aims. The present research aimed the study of the fuorescence of endogenous porphyrins of the skin in patients with acne. Material and methods. 20 patients with acne of 1 – 2 degrees of severity were selected. The main research methodology was a selective colorimetry of tissues with using an electronic photographic devices. The research was led with the use of multiple flters. Image areas were synthesized with high fuorescence, and then a combination of these areas with the source image was produced. The images were processed in ImageJ. Results. The examined patients has revealed intensive red glow in the feld of acne-elements before treatment. After the work with an orange flter pictures were more informative. The study suggests that the chosen method for identifcation of quantitative composition of P. acne appears to be noninvasive and highly effcient.

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Assessment and study of changes psychosomatic state of the vegetative nervous system of patients with rosacea

Year: 2012, volume 8 Issue: №2 Pages: 664-667
Heading: Skin Diseases Article type: Original article
Authors: Utz S.R., Morrison A.V., Davydova A.V.
Organization: Saratov State Medical University
Summary:

Aims. The study aimed an identifying of signs of the vegetative nervous system and detailed study of the psychological characteristics of patients with rosacea. Materials and methods. The study included 60 patients with different clinical forms of rosacea at the age from 26 to 56 years and a control group of 60 relatively healthy persons. The assessment of emotional status is carried out with the survey, Test of accentuations of temperament, Diagnostic Questionnaire Quality of Life Index (DILQ), The Zung Self-Rating Depression Scale, reduced multifactorial questionnaire for the study of personality. Vegetative nervous system was investigated using vegetative Kerdo index, Wayne and Solovyova tables and a special questionnaire for signs of vegetative disorders. Conclusions. Syndrome revealed the presence of vegetative-vascular dysfunction in patients with rosacea with a predominance of parasympathetic tone of the autonomic nervous system. Severity of psychoemotional disorders had no direct relationship to the severity of rosacea. But patients with advanced disease had a tighter self-control on the background of increased excitability and stronger internal emotional stress. Those patients were compared with a group of patients with earlier stage disease, which may provoke functional impairments and in case of long existence-the formation of psychosomatic disorders. This comprehensive assessment of vegetative and emotional status is included in the algorithm for evaluation of patients with rosacea and will successfully complement traditional therapy.

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Pathomorphism in early forms of syphilis today

Year: 2012, volume 8 Issue: №2 Pages: 660-663
Heading: Skin Diseases Article type: Review
Authors: Utz S.R., Zavyalov A.I., Slesarenko N.A., Bakulev A.L.
Organization: Saratov State Medical University
Summary:

The article presents the analysis of literature data and own supervision concerning some changes in clinic of patients with early forms of syphilis.

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Epidemiological features of scabies and STI in the Saratov area from 1991 till 2010

Year: 2012, volume 8 Issue: №2 Pages: 657-659
Heading: Skin Diseases Article type: Original article
Authors: Utz S.R., Zavyalov A.I., Marchenko V.M., Reshetnikova E.M., Yepifanova A.U.
Organization: Saratov State Medical University
Summary:

The study presents the comparative analysis of scabies and STI incidence in different groups of population in Saratov region from 1991 till 2010. Principal causes and factors supporting epidemic process of infectious diseases in this region on an extent of 2 decades are revealed. It is established that if the basic group patients with scabies were children, teenagers and people at the age from 20 to 29 years, so, in the group with STI there were patients aged from 18 to 29 years. Besides, it was proved that over the last years early and late latent forms of syphilis and neurosyphilis prevail among patients in age group from 40 to 60 years. It leads to disability, and sometimes invalidism quite often.

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The case of annular type of pustular psoriasis in a child

Year: 2012, volume 8 Issue: №2 Pages: 654-657
Heading: Skin Diseases Article type:
Authors: Slesarenko N.A., Kulaev K.A., Karakaeva A.V., Russkina O.A.
Organization: Saratov State Medical University
Summary:

This study presents the clinical case of pustular psoriasis in a child. This type of disease is a rare variant of derma-toses in childhood. Due to abnormality of rash localization a differential diagnosis was applied with contact dermatitis, staphylococcus impetigo and rubromycosis.

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The role of vascular disorders in the genesis and maintenance of infammation in the pathogenesis of rosacea

Year: 2012, volume 8 Issue: №2 Pages: 650-654
Heading: Skin Diseases Article type:
Authors: Slesarenko N.A., Leonova M.A., Zaharova N.B., Slesarenko N.S., Reznikova M.A.
Organization: Saratov State Medical University
Summary:

Aims. The study was aimed to identify relationships of immune disorders and angiogenesis in patients at different stages of rosacea. Materials and methods. We examined 110 patients with rosacea. The diagnosis was based on diagnostic criteria. We summarized the role of predictors in the development of rosacea. We investigated pro- and anti-infammatory cytokines, vascular endothelial growth actor (VEGF), fbroblast growth factor (FGF) for the detection of immune disorders and angiogenesis. Results. The immune response in patients with rosacea was of mixed Th-1 and Th-2 type which can be markers of chronic autoimmune infammation. Simultaneously with the change in cytokine profle we revealed activation of angiogenesis (high levels of VEGF, FGF).

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Clinical dermatoscopy of big melanocytic naevuses in patients with psoriasis

Year: 2012, volume 8 Issue: №2 Pages: 646-650
Heading: Skin Diseases Article type: Original article
Authors: Sergeyeva I.G., Krinitsyna J.M., Onipchenko V.V., Makarova N.G.
Organization: Novosibirsk State University
Summary:

The study aimed to determine clinical characteristics of dermatoscopy of big melanocytic naevuses (MN) in patients with psoriasis. Methods. The were 32 patients with psoriasis (11 women at an average age of 37,4 years) and 100 people (79 women at an average age of 27,8 years) with no psoriasis. Both groups had a survey and full photometry screening of skin. Besides Fitzpatrick skin typing test was used, pigmentary formations were examined using dermato-scope HEINE MINI 3000 10X with 70 % ethyl alcohol immersion. Naevuses were estimated by ABCD and ABC scales. Results. MN more than 5 mm in diameter are more often in patients with psoriasis (68,8 %) than in control group (37 %). However in control group there are less naevuses of appropriate dermatological dysplastic formations criteria (32 %) comparison to the group without psoriasis (42 %). There is an important fact that patients with psoriasis often have 2-phototype of skin and artifcial insolation (tanning bed, PUVA, narrow-band phototherapy 311 nm. Conclusion. 68,8 % patients have MN more than 5 mm in diameter. 32 % of patients with psoriasis had MN of dysplastic naevus criteria according to Pehamberger. In one patient naevus was of appropriate malignant tumors criteria according to ABCD and ABC scales.

Keywords: psoriasis
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Case of lichen planus pigmented — аtrophic

Year: 2012, volume 8 Issue: №2 Pages: 643-646
Heading: Skin Diseases Article type:
Authors: Reshetnikova E.M., Utz S.R., Slesarenko N.A., Yeremina M.G., Alipov N.V.
Organization: Saratov State Medical University
Summary:

This study presents a case of a combination of rarely encountered forms of lichen planus (pigmented and atrophic). The results of measurements of indexes of pigmentation and erythema in the lesions and healthy skin are given, and comparing them with different forms of LP. A comprehensive examination of the patient to identify the pathology of internal organs.

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PUVA-bath photochemotherapy in the treatment of psoriasis

Year: 2012, volume 8 Issue: №2 Pages: 639-643
Heading: Skin Diseases Article type: Original article
Authors: Reznikova M.A., Slesarenko N.A., Utz S.R.
Organization: Saratov State Medical University
Summary:

Aims. The study aimed to evaluate the effcacy of PUVA-bath photochemotherapy in the treatment of the severe psoriasis. Materials and methods. Twenty six patients aged from 18 to 56 were examined. All patients suffer from psoriasis vulgaris and exudativa. The two groups were comparable in terms of age, gender, duration of the disease. We used psoriasis area and severity index (PASI) before and after the treatment. All the patients received PUVA bath therapy (aqueous solution of 1 mg ammifurin l). Results. Clinical remission and marked improvement of clinical condition (a 76 % and more fall in the PASI index) were achieved in 80,9 % in both groups in average. No systemic adverse effects inherent in photosensitizing drug tablets were recorded in the course of PUVA-bath therapy. Conclusion. Effciency and safety of this method were demonstrated. The duration and summary dosage of UVA depends on clinical form.

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Effciency and safety of the use of long-wave UVA-1 phototherapy in treatment of psoriasis

Year: 2012, volume 8 Issue: №2 Pages: 637-639
Heading: Skin Diseases Article type: Original article
Authors: Rasskazov Y.A., Kondratyeva N.N., Bakulev A.L.
Organization: Saratov State Medical University
Summary:

The effectiveness of the long wavelength ultraviolet therapy (UVA-1) in complex treatment of patients with psoriasis has been studied during the research. There 20 patients with moderately severe and severe psoriasis in the phase of progressive dermatosis have been observed. The therapy was organized using photobox Waldmann UV-7001K (Herbert Waldmann GmbH & Co, Germany) and F85 100W-TL10R lamps, creating radiation spectrum of UVA-1 (ƛ = 340 – 400 nm) and emission maximum was ƛ=370 nm. 20 patients of the comparison group receive standard therapy in combination with PUVA therapy. The group did not differ from the main group of patients in age, duration and form of the disease. The effectiveness of the treatment was measured according to the dynamic assessment of PASI index. The usage of a long wavelength ultraviolet therapy (UVA-1) has caused a reduction of the severity and the extent of skin lesions, gave positive outcomes in all patients of the study. No adverse effects caused by the therapy undertaken have been noted. The administration of long wavelength ultraviolet therapy (UVA-1) is safe and effective in patients with psoriasis.

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