Saratov JOURNAL of Medical and Scientific Research

Level of circulating cytokines and microelements in patients with hemorrhagic fever accompanied by renal syndrome

Year: 2011, volume 7 Issue: №4 Pages: 863-865
Heading: Infectious Diseases Article type: Short message
Authors: Khasanova G.M.
Organization: Bashkir State Medical University of the Russian Health Care
Summary:

The research goal is to examine the interrelation of cytokines level (INF-y, TNF-a, IL-2, IL-4, IL-10) and concentration of microelements in blood of patients with hemorrhagic fever accompanied by renal syndrome. 292 patients aged 18-59 years have been examined.Enzyme immunodetection has been carried out by using reagents from «Vector-Best» (Novosibirsk). The content of microelements in blood plasma has been estimated by mass spectrometry with inductively coupled plasma (ICP-MS; Elan-9000, PerkinElmer, USA) and atomic emission spectrometry with inductively coupled plasma (ICP-OES; Optima-2000 DV, PerkinElmer, USA). A direct correlation between zinc, selenium, the level of IL-2 and lead, aluminum, the level of TNF-a has been found out. The negative correlation between aluminum concentration and the level of IF-y has been determined

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