Saratov JOURNAL of Medical and Scientific Research

Genetic pathogenesis of essential arterial hypertension (the review)

Year: 2011, volume 7 Issue: №1 Pages: 083-087
Heading: Internal Diseases Article type: Review
Authors: Shevchenko O.V., Svistunov А.А., Borodulin V.B., Ruta A.V., Bychkov E.N.
Organization: Saratov State Medical University, First Moscow State Medical University n.a. I.M. Sechenov
Summary:

It is proved that genetic factors may be considered as fundamental in the development of essential arterial hypertension (AH). Important role in this process belongs to the genes whose products are involved in regulating blood pressure - adrenergic, renin-angiotensin-aldosterone, and homocyclic bradykinin systems. These systems are closely connected by serial and parallel chemical reactions that enable to use genetic testing to determine the state of the whole system. Analysis of polymorphic markers of different groups of genes encoding components of the renin-angiotensin-aldosterone system allows to define the role of each of the pathogenic factor of hypertension in the development of the disease

References (including transliteration from Cyrillic to Roman script)

1.  Puzyrev V.P. Genetika arterial'noj gipertenzii (sovremennye issledovatel'skie paradigmy) // Klinicheskaja medicina. 2003. № 1. S. 12-18.
2.    Naber S.K., Siffer W. Genetics of human arterial hypertension // Minerva. Med. 2004. Vol. 5, № 5. P. 347-356.
3.  Genetics of human coronary vasomotion / C.K. Naber, W. Siffer, R. Erbel, G. Heusch // Arch. Mai. Coeur. Vaiss. 2004. Vol. 97, № 3. P. 255-260.
4.    Lifton R.P, Gharavi A.G., Geller D.S. Molecular mechanisms of human hypertension // Cell. 2001. Vol. 104, № 4. P. 545-556.
5.  Furruck S., Malik M. Renin-angiotensin system: genes to bedside //Am. Heart. J. 1997. Vol. 134, № 3. P. 514-527.
6.   Minushkina L.O. Geny angiotenzinprevrawajuwego fermenta, NO-sintetazy i jendotelina-l i gipertrofija miokarda levogo zheludochka u bol'nyh gipertonicheskoj bolezn'ju korennyh zhitelej Jakutii // Kardiologija. 2005. № 1. S. 41-44.
7.  Zavisimost' mezhdu vozniknoveniem stabil'noj arterial'noj gipertenziej u detej i polimorfizmom genov renin-angiotenzinovoj i kinin-bradikininovoj sistem / A.S. Glotov, T.Je. Ivawenko, G.I. Obrazcova [i dr.] // Molekuljarnaja biologija. 2007. T. 41, № 1. S. 18-25.
8. Rupert J.L., Kidd K.K., Norman L.E. Genetic polimorphisms in the Renin-Angiotensin system in high-altitude and low-altitude Native American population //Ann. Hum. Genet. 2003. Vol. 67, №1. P. 17-25.
9.   Dufour C, Casane D., Denton D. Human-chimpanzee DNA sequence variation in the four major genes of the rennin angiotensin system // Genomics. 2000. Vol. 69, № 1. P. 14-26.
10.  Fu Y, Katsuya T., Asai T. Lack of the correlation between Mbo I restriction fragment length polimorphisms of renin gene and essential hypertension in Japanese // Hypertens. Res. 2001. Vol. 24, № 3. P. 295-298.
11.   Frossard P.M., Lestringant G.G., Malloy M. Human renin gene Bgll dimorphism associated with hypertension in two independent populations // Clin. Genet. 1999. Vol. 56., № 6. P.428-433.
12.  Strong association of a renin intronic dimorphism with essential hypertention / U.Ahmad, D. Saleheed, A. Bokhari, P.M. Frossard // Hypertens. Res. 2005. Vol. 28, № 4. P. 339-344.
13. Amicroarray minisequencing system for pharmacogenetic profiling   of antihypertensive   drug   response   /   U.   Liljedahl,
J.  Karlsson,  H.  Melhus [et al.] // Pharmacogenetics.  2003. Vol. 13, №1. P.7-17.
14. Angiotensinogen 235T allele «dosage» is associated with blood pressure phenotypes/A.C. Pereira, G.F. Mota, R.S. Cunha [et al.] // Hypertension. 2003. Vol. 41, № 1. P.25-30.
15.  Polymorphism of the insertion / deletion ACE and M235T AGT genes and hypertension: surprising new findings and meta-analysis of data / A. Mondry, M. Loh, P. Lui [et al.] // M. VMS. Nephrol. 2005. Vol. 6. P. 11.
16.   Genomewide Linkage Analysis of Weight Change in the Framingham Heart Study / C.S. Fox, N.L. Heard-Costa, R.S. Vasan [et al.] // J. Clin. Endocrinol. Metab. 2005. Vol. 15. P. 3197-3201.
17.  Polimorfnye markery l/D i G7831A gena fermenta, prevrawajuwego angiotenzin 1, i gipertrofija miokarda u bol'nyh arterial'noj gipertoniej / V.A. Brazhnik [i dr.] // Kardiologija. 2003. № 2. S. 44-49.
18.  Effects of ASE l/D and AT1R-A1166C polymorphisms on blood pressure in a healthy normotensive primary care population: first results of the Hippocates study / L.H. Henskens, W. Spiering, H.E. Stoffers [et al.] // J. Hypertens. 2003. Vol. 21., №1. P. 81-86.
19.  A/C1166 gene polymorphism of the angiotensin II type 1 receptor (AT1) and ambulatory blood pressure: the Ohasama Study / M. Kikuya, K. Sugimoto, T. Katsuya [et al.] // Hypertens. Res. 2003. Vol. 26, № 2. P. 141-145.
20.  Polimorfizm gena sosudistogo receptora angioten-zina II i serdechno-sosudistye zabolevanija / D.A. Chistjakov [i dr.] // Ter. arhiv. 2001. № 1. S. 27-30.
21.   Beijing Atherosclerosis Study. Angiotensin II type I receptor gene and myocardial infarction: tagging SNPs and haplotype based association study. The Beijing atherosclerosis study / S. Su, J. Chen, J. Zhao [et al.] // Pharmacogenetics. 2004. Vol. 14, №10. P. 673-681.
22.  Jin J.J., Nakura J., Wu Z. Association of angiotensin II type 2 receptor gene variant with hypertension // Hypertens. Res. 2003. Vol. 26, № 7. P. 547-552.
23.  Bradykinin receptor gene variant and human physical performance /A.G. Williams, S.S. Dhamrait, P.T. Wootton [et al.] // J. Appl. Physiol. 2004. Vol. 96, № 3. P. 938-942.
24.WelchG.,UpchurchG.,LoscaloJ.Hyperhomoceysteinemia and atherothrombosis //Ann. NY Acad. Sci. 1997. Vol. 811. P. 48-58.
25.    Warren S Emergent cardiovascular risk factor: Homocysteine // Prog. Cardiovasc. Nurs. 2002. Vol. 17. P. 35-41.
26.   Homocysteine impairs coronary microvascular dilator function in humans /A. Tawakol, M. Forgione, M. Stuehlinger [et al.]//JACC. 2002. Vol. 40, №6. P. 1051-1058.
27.  Loscalzo J. The oxidant stress of hyperhomocysteinemia // J. Clin. Invest. 1996. № 98. P. 5.
28.   Homocysteine, endothelial dysfunction and oxidative stress in type 1 diabetes mellitus / F. Wotherspoon, D. Laight, K. Shaw, M. Cummings // Br. J. Diabetes Vase. Dis. 2003. Vol. 3 (5). P. 334-340.
29.    Polymorphism of the methionine synthase gene: association with homocysteine metabolism and late-onset vascular disease in the Japanese population / H. Morita, H. Kurihara, T. Sugiyama [et al.] // Arterioscler Thromb. Vase. Biol. 1999. Vol. 19. P. 298-302.
30.  Kupari M., Hautanen A., Lankinen L. Association between human aldosterone synthase (CYP11B2) gene polymorphism and left ventricular size, mass and function // Circulation. 1998. Vol. 97. P. 569-575.
31.   Lask of association between polymorphism of the aldosterone synthase gene and left ventricular structure / H.Schunkert, C.Hengstenberg, S.R. Holmer [et al.] // Circulation. 1999. Vol.99. P. 2225-2260.
 

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