Saratov JOURNAL of Medical and Scientific Research

Complex treatment of patients with malignant cerebral gliomas of supratentorial localization: follow -up results

Year: 2010, volume 6 Issue: №1 Pages: 189-194
Heading: Surgery Article type: Original article
Authors: S.P. Bazhanov
Organization: Saint-Petersburg Scientific Research Institute of Neurosurgery n.a. A.L. Polenov

The aim of the research is to investigate specific antitumor immunotherapy on the basis of autologous dendritic cells in the complex treatment of patients with malignant cerebral gliomas of supratentorial localization. 55 patients with malignant gliomas (41 with glioblastomas, 14 with anaplastic astrocytomas) have been analysed who had received complex treatment with specific immunotherapy. All the patients were hospitalized at complicated disease stages and with tumors over 5 cm in diameter. Specific antitumor immunotherapy was conducted according to the original methodology and included autologous dendritic cells with tumor antigens and tumor cells lysate. Treatment course consisted of autologous dendritic cells introduction on the 10-12th day after the operation. It was performed every 2-3 months. Follow-up results of specific antitumor immunotherapy with autologous dendritic cells were analised. It was noted that lifetime of patients with malignant supratentorial gliomas became longer in comparison with average statistical results. In conclusion it is of importance to point out that specific antitumor immunotherapy included into complex treatment of malignant gliomas allowing to increase disease remission and quality of life

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