Saratov JOURNAL of Medical and Scientific Research

Current Aspects Of Estimation Of Bioradical Imbalance Of Patients With Multiple Sclerosis In The City Of Bryansk (Oxidant Stress And Multiple Sclerosis As An Example Of The Bryansk Population)

Year: 2009, volume 5 Issue: №4 Pages: 584-587
Heading: Neurology Article type: Review
Authors: N.P. Gribova, I.V. Khudyakova
Organization: Smolensk State Medical Academy

Article examines the role of free-radical oxidation of lipids and antioxidant systems in the development and characteristics of MS disease course. Oxidant-antiradical status was assessed in problem research laboratory of Clinical Biophysics, and antioxidant therapy Smolensk State Medical Academy with two direct methods of control - hemolumin-sention and radiospectroscopy and mathematical definition of the integral indexof the bioradical imbalance (coefficient K). Increase of degree EDSS was shown by activation of lipid peroxidation against background of tension in the antioxidant defense system, as well as free radical imbalance, which progressively intensified in direct proportion to rise on disease progression and the gravity of clinical manifestations of disease. Detected changes was determined by disease course and gravity of clinical manifestations of disease. Determined a direct correlation intensity of lipid peroxidation et antioxidant activity processes in patients with MS in ecologically unfavorable areas of the city of Bryansk

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