Saratov JOURNAL of Medical and Scientific Research

№2, 2008, volume 4

CORRECTION OF MICROCIRCULATORY ABNORMALITIES IN CHILDREN WITH DIABETES MELLITUS TYPE 1

Year: 2008, volume 4 Issue: №2 Pages: 100-104
Heading: Pediatrics Article type: Original article
Authors: N.V. Nikolaeva, N.V. Bolotova, V.F. Lukyanov, E.N. Tkacheva
Organization: Saratov State Medical University
Summary:

Article is devoted to investigation of microcilculatory abnormalities in children with diabetes mellitus type 1 and correction with the help of magnetotherapy.

Keywords: diabetes mellitus type 1, magnetotherapy, microcirculation

MEASUREMENT OF BLOOD FLOW IN ARTERIA MENINGEA MEDIA OF PATIENTS WITH FREQUENT EPISODIC TENSION-TYPE HEADACHE NOT ASSOCIATED WITH PERICRANIAL TENDERNESS

Year: 2008, volume 4 Issue: №2 Pages: 95-99
Heading: Neurology Article type: Original article
Authors: E.P. Evdoshenko, L.G. Zaslavsky, A.A. Skoromets
Organization: St. Petersburg Medical University named after academician I.P.Pavlov
Summary:

Twenty seven patients with frequent episodic tension-type headache not associated with pericrania! tenderness (TTH) aged from 18 to 69 years old were examined. Arteria meningea media (AMM) and brachiocephalic arteries (BCA) were examined by supersonic power Doppler scanning during the paroxysm of headache and without the paroxysm of headache. Results: Blood flow in AMM of patients with TTH was significantly different during the paroxysm of headache and without the paroxysm of headache (p0.05). The pattern of hypoperfusion in AMM was displayed in two groups during the paroxysm of headache. The increase of average blood velocity (TAmx) in groups of patients with TTH in comparison with the control group.

Keywords: episodic tension-type headache (ETTH), muscle contraction headache, stress headache, tension headache, tension-type headache (TTH)

CLINICAL-DIAGNOSTIC AND PATHOGENETIC ASPECTS OF CERVICAL DIZZINESS

Year: 2008, volume 4 Issue: №2 Pages: 90-94
Heading: Neurology Article type: Original article
Authors: N.A. Deputatova, I.E. Poverennova, O.V. Zelentsova
Organization: Samara City Hospital №1 named after N.I. Pirogov, Samara Medical and Sanitary Unit №1, Samara State Medical University
Summary:

Questions of occurrence of cervical dizziness at 190 patients with cervical osteochondrosis, anomalies ofcraniovertebral transition and "switch" trauma of a cervical partof the backbone are discussed. On the basis of the results of complex examination with use of ultrasonic and neurovisualization techniques pathogenetic mechanisms of the developmentof cervical dizziness are discussed.

Keywords: cervical dizziness, diagnostics, pathogenesis

ACOUSTIC COGNITIVE CAUSED POTENTIALS (Р300)CHANGES IN CHRONIC ISCHEMIA OF BRAIN

Year: 2008, volume 4 Issue: №2 Pages: 86-90
Heading: Neurology Article type: Original article
Authors: D.P. Garin, I.E. Poverennova
Organization: Samara State Medical University
Summary:

Cognitive infringements represent an actual problem of modern medicine. In elderly men they usually develop on a background of a chronic ischemia of brain (CHBI). P300 research in 134 patients was carried out to define CHBI influence on the basic components of the caused potentials. The group of elderly patients with dyscircularencephalopathy I, II, III stages and group of middle-aged persons with presence CHBI and withoutattributes CHBI were considered. The increase of peaks N2, P3 latency, N2-P3 interpeak interval and decrease of N2/P3 amplitude in elderly patients with positive correlation are revealed depending on the stage of dyscircular encephalopathy. Latency increase and amplitude reduction of the basic components acoustic cognitive potential in middle-aged persons directly correlated with the CHBI presence.

Keywords: chronic ischemia of brain, cognitive caused potential (P300)

CROHN’S DISEASE DIAGNOSTICS IN ACUTE STAGE WITH THE USE OF HIGHLY EFFECTIVE LIQUID CHROMATOGRAPHY BLOOD SERUM

Year: 2008, volume 4 Issue: №2 Pages: 82-85
Heading: Internal Diseases Article type: Original article
Authors: N.N. Mironov, S.V. Nasonov, O.P. Alekseeva, S.V. Krishtopenko
Organization: Gastroenterological Centre of Volga Region Federal District of the Russian Federation, Nizhni Novgorod, Nizhni Novgorod Regional Clinical Hospital named after N.A.Semashko, «Medical Diagnostics» Ltd, Nizhni Novgorod
Summary:

15 patients with the endoscopically and morphologically verified diagnosis of the Crohn’s disease and 14 healthy humans at the age of 23- 24 years have been examined. The Crohn’s disease index activity was 235 - 310 units. The possibility highly effective liquid chromatography blood serum use for diagnosis of the disease has been studied. A blood serum dried extract has been investigated on the "Milichrome A 02" chromatograph (Novosibirsk, "Econova "joint-stock company). The chromatograms have been treated with the use of a multilevel cluster analysis with a pathologic three-measured state form, differing from a healthy human. A diagnostic sensitivity and accuracy of the method has achieved 100%.

Keywords: Crohn’s disease, diagnostics, liquid chromatography

ENDOTHELIAL DYSFUNCTION IN PATIENTS WITH DISTURBED MYOCARDIAL CONTRACTIVE ACTIVITY OF THE LEFT VENTRICLE IN CHRONIC HEART FAILURE PROGNOSIS

Year: 2008, volume 4 Issue: №2 Pages: 76-81
Heading: Internal Diseases Article type: Original article
Authors: N.A Kosheleva, A.P Rebrov
Organization: Saratov State Medical University
Summary:

The aim of the given study was to define antithrombogenic and vasodilative vascular wall activity in patients with disturbed function of left ventricle (LV), developed after Q-myocardial infarction; and to specify its role in chronic heart failure (CHF) prognosis. 40 patients after Q-myocardial infarction were examined; compare five group consisted of 20 patients. Antithrombogenic (anticoagulant and fibrinolytic) and vasomotor activity of vascular wall were determined. It was revealed that disturbance of systolic function of left ventricle in patients with CHF is accompanied by decrease of antithrombogenic and vasodilative vascular wall activity. Patients with IV functional class of CHF having long term CHF and blood release value consisted < 33%; during six months of monitoring the number of repeated unfavourable cardiovascular events was essentially increased.

Keywords: chronic heart failure, endothelial dysfunction

SOME MECHANISMS OF THE DEVELOPMENT DIVERTIKULYARNOY DISEASE OF THE BOWELS

Year: 2008, volume 4 Issue: №2 Pages: 71-76
Heading: Internal Diseases Article type: Original article
Authors: I.V. Kozlova, Yu.N. Myalina
Organization: Saratov State Medical University
Summary:

Stigma dysplasia of connective tissue, indications of diffuse endocrine system (enterocells immunopositive substance P (SP) and vasoactive intestinal polypeptide (VIP), mast cells (mastocyte)) in patients with diverticular disease of bowels are discussed in the article.

Keywords: diffuse endocrine system, diverticular disease of bowels, dysplasia of connective tissue

CHANGE CHARACTERISTICS BLOOD FLOW UTERINE BEFORE LABOR

Year: 2008, volume 4 Issue: №2 Pages: 67-70
Heading: Obstetrics and Gynecology Article type: Original article
Authors: M.L. Chekhonatskay, I.E. Rogozhina, N.E. Yannaeva
Organization: Engels Perinatal Centre, Saratov State Medical University
Summary:

The article deals with research findings of uterus and uterus cervix blood flow in 120 healthy pregnant women in 37-42 weeks gestation period by transabdominal and transvaginal ultrasonic determination. The researches carried out have revealed marked interrelation between characteristics of uterus blood flow changes and the date of labor. In the last two weeks of gestation there is an intensification of uterus cervix blood supply and before labor there is a filling of uterus cervix with blood due to the increasing of venous vessels number and volume

Keywords: blood flow uterine before labor

PROTEIN C ROLE IN MICROCIRCULATION DISTURBANCE IN PATIENTS WITH GINGIVITIS

Year: 2008, volume 4 Issue: №2 Pages: 61-63
Heading: Physiology and Pathophysiology Article type: Original article
Authors: V.F. Kirichuk, T.V. Simonyan
Organization: Saratov State Medical University
Summary:

The research purpose is focused on studying the role of protein С system in coagulation component disturbance of hemostasis and fibrinolysis system in patients with different forms of gingivitis.
The decrease of protein С and antithrombin inactivity, the decrease ofplasminogen reserve in blood, thrombin time shortening and the resistance of factor Va Via to protein Care watched in patients with different forms of gingivitis. The most marked changes in protein С system may be observed in exacerbation phase of acute and chronic ulcerative generalized gingivitis and chronic catarrhal generalized gingivitis. The reduction of indices of protein С system doesn’t occur in remission phase except in patients with chronic catarrhal ulcera five generalized gingivitis

Keywords: gingivitis, microcoagulation disturbance, protein C

THE METHICILLIN-RESISTANCE MEASURE OF STAPHYLOCOCCI CLINICAL STRAINS

Year: 2008, volume 4 Issue: №2 Pages: 56-60
Heading: Microbiology Article type: Original article
Authors: N.G. Khodakova, G.M.Shub, I.G.Shvidenko
Organization: Saratov State Medical University
Summary:

Staphylococci playa great role in the emergence of various human illnesses. The most actual are infections caused by methicillin-resistant staphylococci.
The study of methicillin susceptibility as a polyresistance marker includes the definition of the minimum inhibitory concentration (MIC) of antibiotic which in vitro fully suppresses the visible growth of microorganisms in the standard experiment conditions and is expressed in absolute figures (mg/l or mkg/ml).
The aim of the research is the measure of MIC methicillin (oxacillin) for the clinical strains of staphylococci isolated from different clinical specimens and comparative analysis antibiotic’s MIC for Staphylococcus aureus and coagulase-negative staphylococci (CNS).
The resultofthe research is the determination of the oxacillin concentration preventing growth of the methicillin-resistant clinical strains ofS.aureus and CNSwhich were detected from different profile hospitals of Saratov- general hospital №2, maternity hospital №6, children’s regional hospital and centre ofcombustiology.
The methicillin-resistant of the staphylococci clinical strains in the Saratov region has not been investigated before.

Keywords: strains, staphylococci, polyresistance, oxacillin, methicillin